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Spyre Therapeutics Inc
221 Crescent Street, Suite 105
Phone: (617) 651-5940p:617 651-5940 WALTHAM, MA  02453  United States Ticker: SYRESYRE
Business Summary
Spyre Therapeutics, Inc. is a clinical-stage biotechnology company, specializing in long-acting antibodies and antibody combinations for inflammatory bowel disease (IBD) and rheumatic diseases. The Company's pipeline includes investigational extended half-life antibodies targeting a4b7, TL1A, and IL-23. It is advancing a pipeline of monoclonal antibodies (mAbs) for the treatment of IBD and other immune-mediated diseases. The Company's pipeline includes its SKYLINE Phase II platform trial evaluating SPY001, SPY002, SPY003, and pairwise combinations thereof in subjects with moderately to severely active UC and its SKYWAY basket trial evaluating SPY072 in three rheumatic diseases: rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondyloarthritis (axSpA). SPY001 is a highly potent, highly selective, and humanized monoclonal immunoglobulin G1 investigational antibody designed to bind selectively to the a4b7 integrin being developed for the treatment of IBD (UC and CD).
(Source: 6-K)

Scores and Ratings
FRISK®
Score		 Z''
Score		 PAYCE®
Score		 DBT
Index		 Moody's
Rating		 Fitch
Rating		 DBRS
Rating
YesYes-Yes---

Financials, News and Filings
Latest
Statement		 Last
Audit
News		 SEC
Filings		 Bankruptcy
Filings		 Suit &
Judgment
Filings		 Tax
Lien
Filings
3/31/202612/31/2025YesYes--Yes

Industries
SIC Code Description
2834 Pharmaceutical preparations
8731 Commercial physical and biological research

Officers and Directors

Title
Name
Age		 Title
Date		 Start
Date
Independent Chairman of the Board Jeffrey W.Albers 54 1/1/2024 11/22/2023
Chief Executive Officer and Director CameronTurtle 36 11/22/2023 6/22/2023
Chief Financial Officer Scott L.Burrows 49 9/1/2023 9/1/2023
6 additional Officers and Directors records available in full report.

Subsidiaries
Business Name Address City State/Province Country
Aeglea Biotherapeutics UK Limited Oak House, Tanshire Park Elstead Surrey United Kingdom

Business Names
Business Name
Aeglea Biotherapeutics UK Limited
Aeglea Ireland Limited
AGLE
Spyre Therapeutics, Inc.
SYRE

General Information
Number of Employees: 112 (As of 3/31/2026)
Outstanding Shares: 86,841,253 (As of 4/28/2026)
Shareholders: 24
Stock Exchange: NASD
Federal Tax Id: 464312787
Fax Number: (302) 636-5454


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Sunday, June 21, 2026